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Resident Evil Retrospective – Part 5: Leon vs. Las Plagas

In 2001, Capcom announced what would become one of the most pivotal entries in video game history: Resident Evil 4. As part of an exclusivity deal with Nintendo, Resident Evil 4 was initially planned to be part of the “Capcom 5,” a collection of five titles intended to boost the GameCube's popularity. Alongside P.N.03, Killer7, Dead Phoenix, and Viewtiful Joe, Resident Evil 4 promised to take the series in a bold new direction. A remake of the original Resident Evil and a prequel, Resident Evil 0, were also on the horizon. However, the journey to release would prove to be anything but straightforward.



A New Direction for Leon S. Kennedy

Before it became the masterpiece we know today, Resident Evil 4 underwent several iterations. The only element Capcom was certain of from the start was that the protagonist would be Leon Kennedy, the familiar Resident Evil 2 hero. However, this wouldn’t be the Leon fans knew. Instead of the skinny redhead from Raccoon City, Leon would evolve into a more rugged, muscular figure. The story’s setting also shifted, leaving behind the familiar urban environments of previous games for a mysterious European locale.



The game's first appearance at the 2002 Tokyo Game Show gave players a glimpse of this new direction. Leon was shown battling supernatural enemies in ominous locations like a haunted mansion and a lightning-swept airship. Capcom hinted at Leon becoming infected by an early form of the T-virus, while a menacing foe wielding giant scissors stalked him. Despite the eerie atmosphere, this version was soon scrapped as the developers decided it wasn’t the right fit for the series.



The second attempt debuted at E3 2003, where the game shifted toward paranormal horror. Leon found himself taunted by haunting dolls and shadowy figures, with the centerpiece enemy being an invulnerable phantom swinging a chain and hook. Although this iteration introduced the now-iconic over-the-shoulder camera and laser-guided gunplay, it too was abandoned. Capcom’s Shinji Mikami, the driving force behind the series, realized the paranormal elements didn’t suit the franchise's core themes and pushed to take the game in yet another direction.



Reimagining Survival Horror

Determined to create something fresh while staying true to the series’ identity, Mikami wanted Resident Evil 4 to stand apart from the classic zombie formula. Drawing on his experience directing P.N.03 and producing Viewtiful Joe, Mikami reinvented the game with a focus on faster, more aggressive enemies. Gone were the slow-moving Romero-style zombies; in their place were the frighteningly intelligent and violent villagers of rural Spain, known as Los Ganados.



When Resident Evil 4 finally launched on January 11, 2005, for the GameCube, it took the series in a groundbreaking new direction. Set six years after the events of Resident Evil 2, the game follows Leon, now a U.S. Secret Service agent, on a mission to rescue the kidnapped daughter of the U.S. President, Ashley Graham. His mission leads him to a secluded village in Spain, where a sinister cult, Los Illuminados, is using a parasitic organism known as Las Plagas to control the local populace.



For the first time in the series, Umbrella Corporation—the malevolent pharmaceutical company that had been central to the plot—was largely absent. The focus was now on a new biological threat, making Leon’s journey feel fresh while maintaining the tension and horror the series was known for.



Revolutionary Gameplay Changes

Resident Evil 4 introduced several gameplay innovations that forever changed the survival horror genre. Most notably, the shift to a fully 3D, over-the-shoulder perspective brought players closer to the action. This new viewpoint, combined with laser-guided targeting, gave players more control over combat than ever before. Leon’s enemies, the Ganados, were a far cry from the mindless zombies of previous games. They could work together, dodge bullets, and use weapons—forcing players to adapt to a faster, more strategic style of gameplay.



The game’s structure was also significantly altered. Gone were the static, pre-rendered backgrounds and restrictive item slots of earlier titles. Players could now freely explore vast environments and organize their inventory within an upgradable attaché case. Items could be sold to a mysterious traveling merchant, who quickly became one of the series' most memorable characters with his iconic line: “Got a selection of good things on sale, stranger!”



Another significant departure was the removal of the ink ribbon system, which had limited saves in earlier games. Instead, players could save their progress at typewriters without needing an item, reducing the frustration of limited saves and allowing for a more streamlined experience.



The Evolution of Horror

As Leon's mission unfolded, he faced increasingly dangerous foes. From the aggressive Ganados to monstrous creations like the El Gigante and the parasitic Regenerators, the enemies in Resident Evil 4 were as diverse as they were terrifying. The game also introduced Quick Time Events (QTEs), which added a new layer of interactivity to cinematic moments. These button-pressing sequences kept players engaged during intense cutscenes, ensuring that even watching the action felt dynamic.



While Resident Evil 4 moved away from traditional survival horror in many ways, replacing puzzles with more action-oriented gameplay and increasing the availability of ammunition, it still retained an atmosphere of dread and tension. The line between hero and villain blurred as Leon discovered that the Ganados were victims, controlled by the Las Plagas parasite. This added a tragic dimension to the relentless violence Leon was forced to inflict on the villagers.



Legacy and Impact

Resident Evil 4 was a monumental success, both critically and commercially. It won over 20 Game of the Year awards, sold millions of copies, and was hailed as one of the greatest video games of all time. Its influence extended far beyond the Resident Evil series, reshaping the survival horror genre and inspiring numerous other games to adopt its innovative mechanics.



However, not all fans embraced the changes. Some long-time players lamented the loss of the traditional slow-burn horror and puzzles that had defined the earlier games. The focus on action and shooting over suspenseful exploration led some to criticize the game for abandoning the core principles of the series. Still, Resident Evil 4 represented a bold evolution, and its legacy as a revolutionary entry in the franchise is undeniable.



A New Era for Resident Evil

Following the release of Resident Evil 4, the franchise would continue to evolve in new and unexpected ways. The game was eventually ported to multiple platforms, including the PlayStation 2, PC, and Wii, each version bringing new features and costumes for Leon and Ashley. The success of Resident Evil 4 also helped pave the way for new Resident Evil films and animated features, further expanding the series’ reach into mainstream pop culture.



Despite the growing pains the series experienced in the 2000s, Resident Evil 4 remains a defining moment in video game history. It showcased Capcom’s willingness to take risks and reinvent a beloved franchise, proving that even the most iconic series can evolve while staying true to its roots. Whether fans embraced the action-heavy direction or longed for the more traditional survival horror experience, Resident Evil 4 set the stage for the future of the series—and the survival horror genre itself.



In the next chapter of this retrospective, we’ll dive deeper into the mysteries of Resident Evil, exploring Umbrella’s dark history and the forces that continue to shape the series' ever-expanding universe.

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